Nyengo yachiwiri ya nkhani ya sayansi ya Pandora imayamba pa CW njira ya Okutobala 4, ndipo chifukwa chake opanga adapereka mawu atsopano. Munthawi yoyamba, Jacqueline "Jax" zhuu adawulula chinsinsi chachikulu: iye ndi Pandora, ndiye kuti, cholengedwa chomwe chimatsimikizira tsogolo la chilengedwe chonse. Ngakhale JackS ndi abwenzi ake ayenera kupulumutsa chilengedwe chonse, pali lingaliro loti chiwonongeko chayamba kale. Kuphatikiza pa jacks, odzigudubuza amawoneka kale onse odziwika kale ndi nkhope zatsopano.
Zochita "Pandora" zikuchitika mu 2199. Nkhanizi zikufotokoza za mtsikana wa Jacks (Priscilla Quintaan), yomwe imabwereranso padziko lapansi kuchokera ku chilengedwe cha chilengedwe pambuyo pa banja lake lonse litamwalira. Chiwerengero chaching'ono choyambitsa moyo watsopano, ngwazi zake zimalowa maphunziro a maphunziro a Space. Kumeneko, a Jack ndi abwenzi ake amaphunzira kuteteza mlalang'ambawu kuchokera ku zoopsa zonse - zonse za anthu komanso zowonjezera. Nthawi yomweyo, a Jacks ayenera kuphunzira kupezeka kwawo komanso gawo lapadera pa tsogolo la chilengedwe chonse.
Showranner "Pandora" ndi Marko A. Oltman ("Wofunika Wankhanza", "Zokongoletsa Zowopsa"). Mu nyengo yachiwiri, kuwonjezera pa quintans, Oliver TELD imabwereranso ku maudindo awo akale (Kaputeni a Danland), John Harl Kim (Gren Lee) ndi Runlen Ralen). Komanso, mndandanda udzasewera Akshai Kumar (Jett), Roxanna McKay (Eva, akuti akumwalira amayi a Jalks) ndi Tina Kaskiani (Tarnni, mtsogoleri wa bungwe la Assimia Stremite).