Yayobowe na Paul U.S. Anderson warashe filime ya mbere "ikibi ikibi", nyuma asubira mu cya kane na gatanu, azahinduka abagenewe kurangiza. Itariki yo gukodesha yasubitswe kubera kwitaba inda yatwitse ya Yovovich, umugore w'igihe gito ni umugore w'umuyobozi. Anderson ubwe na we yanditse inyandiko ku gice cya nyuma, "kuba umuturage wa 6", kandi akora nk'umwe mu babyara. Usibye inyenyeri nyamukuru yishusho, Milla Yovovich, Ian Glen Glen Kuva "Umukino w'intebe", Umukinnyi w'intebe ", Umukinnyi w'intebe", Oran Roser n'ibice bya kane "umuturage mubi".
Imyaka 4 irashize kuva igice cyabanjirije iki, na kaseti "abatuye 6" akomeza inkuru yawe. Nyuma yo guhemukira induru ya veszer ya veszer, ihinduka wenyine ushobora guhindura inzira yamateka. Kugira ngo akore ibi, agomba gusubira mu mujyi wa Rakkun kugira ngo yinjire guhangana na corporation ya Ambrell. Isi yose ibangamiwe no kuzimira, no gukumira ibi, Alice hamwe nabafatanyabikorwa bayo bagomba gutsinda imbaga ya Monsters yamaraso. Ariko intego yarwo nyamukuru ni ugusenya umuzi wibibi, inzira izajya igoye kandi yamahwa.