Ntabwo abantu bose bafite intego ya firime hamwe nabafana ba selial bazi mumaso, ariko uhereye kuriyi rukundo rwabo ntabwo ari munsi. Nibyo byabaye kuri Mama Howard volovitsa (Simon Helberg (Simoni Helberg) avuye muri "nyigisho yo guturika kwinshi". Ku bihe umunani, abari bateraniye aho, abahoze mu bakinnyi bakinnyi Carol annn, maze aba ikarita y'ubucuruzi nyawe.
Abafana bamenye bwa mbere iby'uko Madamu Volovitz kuri 7 y'ibice byambere byo kwerekana, iyo inshuti zafashe umwanya wa nijoro kuri Leonard (Johnny Galeki) na Shelsons (Jim Parsons). Nyuma yibyo, abaremwe ba rukurikirane ntibabuze amahirwe yo kumira kuri Howard bobo ubwabo n'ubuzima muri rusange kubera amagambo menshi Debbie yasohotse.
Howard na nyina bari hafi cyane, kandi byabaye inshuro zirenze imwe impamvu yo guhuza inshuti ze, uwo ari we, usibye ko, usibye ko yishimiye guseka no hejuru y'ijwi rya Madamu volovitz. Nubwo bimeze bityo ariko, igihe yapfaga, abantu bose bari bajanjaguwe rwose n'aya makuru kandi ubushyuhe bwibutse ibihe bibi aho Debbie hari ukuntu byagize uruhare rwa Mama kuri buri wese muri bo.
Debbie yapfiriye mu nzozi mu gihe mu rugendo rwo gusura mushiki we, kandi ntibyari bitunguranye, kuko, kubera ko, nta kibazo cyerekanaga ko yari arembye cyane. Icyemezo cyo kurangiza ikibanza cya Debbie cyahatiwe. Ikintu icyo aricyo gihe, nyuma yo guharanira kuva kera na kanseri, susie ubwayo. Kandi nibura umukinnyi wa filime ntabwo yigeze agaragara mu kimenyetso ku mubiri, abafana barabikuye ku mutima.
Kwerekana guhaga Carol Ann Bikwiye, kandi abareba byitondeye cyane bashoboraga kubona ifoto yumukinnyi wa firiba muri firigo mu nzu ya Sheldon na Leonard. Byongeye kandi, tubikesha inyandiko zabitswe, ijwi rya Debbi ryasubiye mu byiciro Howar mu gihembwe cya cumi na rimwe.