Mid ka mid ah daawadayaasha ugu caansan ee jilayaasha "anatomy kalgacal", Joe (Camilla Leedinshaton), ayaa dhowaan tijaabooyin badan ku dhacay. Dhamaadka waxkasta, waxaa ka hadhay nin la'aan, sida geesiga si lama filaan ah uga tagay taxanaha Tacabka Justin Chimex Trex Karev uu go'aansaday inuu socdo wadada khiyaanada.
Daawadeyaashu waxay ogaadeen in Joe si la yaab leh dib loo dhigo warkaas in Alex uu diiday inuu xiriir la yeesho iyada aawadood nolosha IZHI (Catherine heyigl) iyo mataanadooda dhasha. Waxay soo baxday in Crista Verniff uu si ula kac ah u oggolaaday dabeecadda Laddington ee aan lagu hafin karin silica, maahan oo keliya in la saaro bini-aadamnimada, laakiin sidoo kale u diyaarso ciidda horumarka kale ee sheekada.
Mid ka mid ah wareysiyada, ayuu Showranner qirtay inuusan diyaar u aheyn inuu ku qasbo Joe inuu silicayo, ka dib xilli ciyaareedkii 15aad oo uu la kulmay cilad maskaxeed, oo baratay waxa ku dhashay kufsiga ka dib kufsiga.
Waxay ka badbaaday dhowr bilood oo calool xumo, oo ma aanan dooneynin inaan aragno sida Joe lagu dhex dhimay xaaladan,
- Usheegtay Vernoff.
Sidoo kale, soosaaraheeda ayaa la wadaagey in nolosheeda ay jirto waayo-aragnimo markii "Xanuunka jahliga ka dhashay uu ka sii dartay runta dhaawacan, sidaas darteed waxay u aragtay inay daacad u tahay indton-ka uu u sheego waxa ka dhacay Alex. Waxay carrabka ku adkeeyay in "Joe uu metelay xaaladaha ugu xun, ugu yaraan mid ka mid ahina waa run, helitaanka macluumaad ayaa u oggolaaday inay u dhaqaaqdo," tanina waa run.
Taxanaha "Anatomy ee kalgacalka" ayaa horay loo kordhiyay 17-kii xilli, laakiin ma cada markii dhagaystayaashu ay awoodi doonaan inay arkaan dhacdooyin cusub, maxaa yeelay faafitaannada coronavirus-ka ee Coronavirus ayaa si lama filaan ah u saameyn doona jadwalka toogashada.