Ilathwe nguPaul U.S. UAnderson owayedubula ifilimu yokuqala "ububi bokuqala", kwaye kamva wabuya ekubuyeni kwesine nakwesihlanu, uya kuba ngabo bamiselwe ukugqiba le franchise. Umhla werente wahlehliswa ngenxa yokukhulelwa kwi-Poollovich Yovovich, olixesha elininzi ngumfazi wenkokeli. I-Anderson ngokwakhe iphinde yabhala iscriptor yenxalenye yokugqibela, yaza yaba ngomnye wabavelisi. Ukongeza kwinkwenkwezi ephambili yomfanekiso, i-Milla Yovovich, ian Glen Glen ukusuka kwi-"Gapan Robers ukusuka kumalungu adlulileyo, i-Sean Roberts ukusuka kwixesha lonyaka") kunye ne-Ellie Larter evela kwisithathu Inxalenye yesine "ingumhlambi wobubi".
Sele idlule iminyaka emi-4 ukusukela kwinxalenye yangaphambili, kwaye ikhasethi "i-Preysed ingendawo 6" iyaqhubeka nebali. Emva kokungcatshelwa kwe-veszer eyoyikisayo, uAlice iba kuphela komntu onokutshintsha ikhondo lembali. Ukwenza oku, kuya kufuneka abuyele kwi-rakkun yesixeko ukuba ajoyine impikiswano ne-Ambrell Corporation. Ilizwe liphela liphantsi kwesoyikiso lokutshabalala, kwaye ukuthintela oku, u-Alice kunye nolwalamano lwalo kuya kufuneka boyise i-horders yee-throni zegazi. Ke yona imbeko yalo kukutshatyalaliswa kwengcamba yobubi, Imendo iyele ngqiqweni, inameva.