I-tentasy yedrama "Izithixo zaseAmerican" ezisekwe kwinoveli ye-Nila Gamedan ibala malunga nendoda egama linguMthunzi, owathi emva kokuyeka intolongo iba yi-protégis yoLwesithathu uMnu. Emva koko, isithunzi siguqukele sibandakanyeke kwimfazwe e-Epic phakathi koothixo ababizwa ngokuba nowandala.
UBrian Fuller noMichael Green, uBian Gedeler noMichael Green, baba ngamantshontsho e-Destian thematies kunye nabavelisi beprojekthi bayishiya izithuba. Umhla wokulandela yayinguYese uAlexander, kodwa wagxothwa ngexesha elifanelekileyo ngenxa yokuba abaphathi bengayithandi iindlela zokuphela ezinikelwe kubo. Ngokudibeneyo kunye noluhlaza ovela kuluhlu, amagcisa uGillian Anderson (amajelo amatsha kaThixo), uChristine Hones (kunye no-Ostara Jones (Mnu. Nus Nancy).
UCharles H. Andi, owayekwazile ukusebenza kwi "Dexter" nexesha lexesha lokuhamba kwabafileyo, uya kuba noxanduva lokuveliswa kwesithongisithathu "thixo". I-RICKY WOWNTLE, EMNYER Brown, ian Mcshin, i-Crispin Glover kunye ne-Pablo Shreiber iza kubuyela kwindima yabo eqhelekileyo. Ukongeza, uMarilyn Manson, uDanny Triho, Blytun Dunner no-Ivan Reon wajoyina into esebenzayo.