Iqondiswe nguPaul U.S. U-Anderson owadubula ifilimu yokuqala "ehlala ububi", futhi kamuva wabuya ngolwesine nolwesihlanu, uyoba yilabo abahlelelwe ukuqeda leli franchise yesikhathi eside. Usuku lokuqasha luhlehlisiwe ngenxa yomdlalo wokukhulelwa uYovovich, okuyingxenye yesikhathi somholi. U-Anderson uqobo wabhala iskripthi sengxenye yokugcina, "umhlali okubi 6", futhi wenza njengomunye wabakhiqizi. Ngaphezu kwenkanyezi eyinhloko yesithombe, i-Milla Yovovich, i-Ian Glen Glen evela ku- "Game of Threen", uSean Roberts kusuka ezingxenyeni ezedlule, umlingisi we-ruby rose ("i-orange - ukushaya kwesizini") kanye no-Ellie Fout kusuka kwesithathu nezingxenye zesine "Isakhamuzi Esibi".
Sekuvele iminyaka emi-4 sekudlule ukulethwa kwengxenye yangaphambilini, kanye nethiphu "Resident Evil 6" iyaqhubeka. Ngemuva kokukhaphela okubi kakhulu kweVeszer, u-Alice uba ukuphela komuntu ongashintsha inkambo yomlando. Ukuze wenze lokhu, kuzofanela abuyele eRakkun City ukujoyina ukuxabana ne-Ambrell Corporation. Umhlaba wonke usongelwa ekuqothulweni, futhi ukuvimba lokhu, u-Alice kanye nababambiswano bawo kuzofanela banqobe izindimbane zegazi lezilo. Kepha inhloso yawo eyinhloko ukucekelwa phansi kwempande yobubi, indlela eya kuyokwayo.