Akuzona zonke izinhlamvu ezinenjongo zamafilimu kanye nabalandeli be-serials abazi ebusweni, kepha kulolu thando lwazo aluncane. Yilokho okwenzeka kuMama Howard Volovitsa (uSimon Helberg) kusuka "emcabangweni wokuqhuma okukhulu". Ngezinkathi eziyisishiyagalombili, izilaleli zezwakala kuphela izwi lomlingisi uCarol Ann Huszy, futhi waba yikhadi lebhizinisi langempela lochungechunge.
Abalandeli baqale bafunda ngokuba khona kukaNkk Movovitz ngeziqephu eziyi-7 zesikhathi sokuqala sombukiso, lapho abangane bethatha iHoward yobusuku baye kuLeonard (Johnny Galeki) noSheldon (Jim Porsons). Emva kwalokho, abadali bochungechunge abaphuthelanga ithuba lokugwinya ku-Howard uqobo kanye nokuphila okuphelele ngenxa yezitatimende ezinkulu ezixoshwe.
UHoward nonina babesondele kakhulu, futhi kwaba ngaphezu kwesizathu sokuxhaswa kwabangane bakhe, ngubani, ngaphandle kwalokho, bahlale bejabule ukuhleka naphezu kwezwi likaNkk Molovitz. Noma kunjalo, lapho eshonile, wonke umuntu wayephoxekile yilezi zindaba futhi ngemfudumalo ekhumbula izimo lapho uDebbie ngandlela thile adlale ngayo indima kamama ngamunye wabo.
UDebbie ushone ephusheni ngesikhathi sohambo lokuvakashela udadewabo, futhi bekungalindelekile, ngoba, naphezu kwezinkinga zakhe zempilo, akukho lutho olukhombisa ukuthi wayegula kakhulu. Isinqumo sokuqedela umugqa wesakhiwo uDebbie waphoqwa. Le nto leyo yilapho-ke, ngemuva komzabalazo omude nomdlavuza, ngokwayo. Futhi okungenani umlingisi akazange avele embukisweni ngokomzimba, abalandeli bakhala ngobuqotho ukunakekelwa kwakhe.
U-Showranner wanikeza uCarol Ann ngenxa, kanti izibukeli ezilalelisisa kakhulu zabona isithombe somlingisi esiqandisini esiqandisini efulethini likaSheldon noLeonard. Ngaphezu kwalokho, ngenxa yamarekhodi agciniwe, izwi likaDebbi libuyele ezikhumbuzweni zikaHoward ngesizini eshumi nanye.