"I-Anatomy of Passion" ibuyile ezinsukwini ezimbalwa ezedlule kwizikrini ngemuva kwekhefu lezinyanga ezimbili, futhi abalandeli abasevele bebazi ukuthi ama-cherbes (alex karev) ngeke asaba khona ochungechungeni, bekujabulisa kakhulu ukubona ukuthi icebo kuzothuthukisa ngemuva kokunakekelwa okungalindelekile umlingiswa obaluleke kangaka.
Kwavela ukuthi uShunda Rims Showranner walungiselela incazelo elula kakhulu yababukeli bokunyamalala kukaKarev. Kwezinye zezikhathi zesiqephu, lapho iMeredith Grey (Ellen Pompee) yeza ukuzovakashela unkosikazi ka-Alex Joe (Camilla Laddington), wathi wayesekunina e-Iowa. Futhi akukho okuveze ukuthi wahamba ngenxa yesimo esithile esibuhlungu. Ngakho-ke, kumbungi ongenalwazi, ukunyamalala kweqhawe kubukeka njenge-storyline ejwayelekile.
Kepha kungekudala, kusazodinga ukuchaza ngokunengqondo ukuthi kungani umlingisi obambe iqhaza elibalulekile ochungechungeni lweminyaka engu-15, ngokuzumayo anyamalale. Kuyiqiniso, indlela elula kakhulu yokuphuma yayingaba "ukubulala" uKarev, bese kuthi indaba kaJoe ingahamba njengowesifazane, yize ngemuva kwesikhathi esithile egcwele usizi. Kepha kungenzeka ukuthembela eqinisweni lokuthi ama-Herber azovuma ukubuyela endaweni yokudubula ukuze asebenze endaweni yesehlakalo sokuvalelisa, akukufanele.
Kuyiqiniso, ukubheka ukubaluleka kombukiso kanye nesipiliyoni somkhiqizi, awukwazi ukungabaza ukuthi iqembu lokudala lisazothola indlela enhle yokuchaza ukunyamalala kokugcina kuka-Alex, ngaphandle kokudumaza abalandeli.