Isizini yesibili yochungechunge lwesayensi yesayensi i-Pandora iqala esiteshini se-CW ngo-Okthoba 4, ngakho-ke abadali baveze isilulumagama ochungechungeni olusha. Ngesizini yokuqala, uJacqueline "uJax" uZhou uveze imfihlo enkulu: UnguPandora, okungukuthi, isidalwa esinquma isiphetho sendawo yonke. Ngenkathi ama-jacks nabangane bayo kufanele basindise indawo yonke, kukhona umbono wokuthi imbubhiso isiqalile. Ngaphezu kwamaJacks, i-roller ivela ngezinhlamvu zombili ezijwayelekile nobuso obusha.
Isenzo esithi "pandora" sembula ngo-2199. Uchungechunge lukhuluma ngowesifazane osemusha waseJacks (uPriscilla Quintan), obuyela emhlabeni eDale Dale ngemuva kokushona komndeni wakhe wonke. I-Inemenial ukuqala impilo entsha, i-heroine ingena esikhungweni sokuqeqeshwa kwesikhala semikhumbi. Lapho, ama-jacks nabangane bakhe bafunda ukuvikela umthala kuzo zonke izinhlobo zokusongela - umsuka womuntu nangokwengeziwe. Ngasikhathi sinye, amaJacks kufanele afunde ubunikazi bawo bangempela kanye neqhaza elihlukile ekufezekisweni kwendawo yonke.
I-Showranner "Pandora" nguMark A. Oltman ("enesihluku esidingekayo", "ubuhle obubulalayo"). Ngesizini yesibili, ngaphezu kwama-quintan, u-Oliver Dench uzobuyela ezindimeni zawo zangaphambili (uCaptain Xander Duval), uJohn Harlan Kim (Greg Lee) noBen Radcliffe (inyoplan Ralen). Futhi, uchungechunge luzodlala i-Akshai Kumar (Jett), uRoxanna McKay (u-Eva, okusolwa ukuthi ushona omama uJacks) noTina Karkianiani (uTarnni, umholi weCriminal Organ Hydatia syndatia).