Phambilini, uLindsay Lohan uveze isifiso sakhe sokubanjwa ekuqhubekeni kwamantombazane "omisiwe":
Kubukeka kimi ukuthi kufanele ngibuyele kuma-movie kungekudala. Ngingathanda ukwenza "amantombazane omisiwe 2," Ukusebenzisana noTina Fay, amanzi amamaki nalo lonke iqembu. Kuyathakazelisa kakhulu.
Manje wasekelwa nguRachel Makadams. Okungenani, emsebenzini wakhe, umlingisi oboshwe ngamafilimu ahlukahlukene, okuvela kumaphrojekthi e-indie kuma-verlock holmes noRobert Dolor Junior no- "Dr. Strandja" Marvel, kusahlanganiswa nezilaleli kuqala Iqhaza likaRazhina uGeorge ovela ku- "Amantombazane Omisiwe". Ukudlala i-Anagenthan Makadams enkulu, ephendula imibuzo yabalandeli, kusho:
Kungaba kuhle futhi ukuthi udlale uRegina George futhi ngesikhathi esisha sempilo yakhe futhi ubone ukuthi impilo yakhe iye yathuthuka kanjani.
Izibukeli kufanele futhi zibe nentshisekelo yokubheka ukubuya kukaRegina George. Ngemuva kwakho konke, kwifilimu yokuqala wayeyintombazane ethandwa kakhulu yesikole, indawo yakhe ezama ukuthatha uCade Chiin, odlalwa yiLindsi Lohan. Ngenxa yengxabano phakathi kwamantombazane eRegina, iwela ngaphansi kwebhasi, futhi uCadei wonke umuntu usola emzameni wokubulala umphikisi wakhe.