Enkulumweni yakhe, charlize therlize akazange abizele kuphela umphakathi wezwe ukuzama ekugcineni ukunqoba ubhubhane lwe-AIDS ngonyaka ka-2030, kodwa futhi washo nokuthi kulolu daba kuyadingeka ukwenza ukubheja esizukulwaneni esisesimini, ngoba bekulokhu kushintsha injini. Ukwephula ama-stereotypes, abantu abasha bazokukwenza ngokushesha kunabantu abangakwazi ukuxazulula le nkinga amashumishumi eminyaka.
Ekhuluma ngenkulumo, charlize kwaholela ezibalo ezidabukisayo, ngokusho ukuthi imiphumela yomsebenzi wezinhlangano olwa kanzima nengculazi ayinathemba kakhulu. Ngokusho kukaCharlize Theron, isizathu sangempela salesi sifo asikanqotshwa, kuyehlela ukuthi izimpilo zabathile zibaluleke ngaphezu kwezimpilo zabanye, izingxenye ezisengozini kakhulu zabantu azinakwa.
Engqungqutheleni ye-AIDS, charlize wethule iphrojekthi yayo "yofuzo". Inhloso yalo mbhalo ukuheha isizukulwane esisha, mthukuthelise ukuba anqobe ukungabi nabulungisa emphakathini, okuthi, ngokusho komsebenzi, "ekhubaza umhlaba esiphila kuwo." Ukudluliswa kwakhe akugcini ekulweni nengculazi - Charlize Theron futhi amaphupho okuhlulwa kobuhlanga, ubumpofu nobuphofu.