Idrama eqhubekayo yezokwelapha "i-anatomy of Passion" esiteshini se-ABC somlando wakhe oneminyaka eyishumi nesikhombisa yalahlekelwa izinhlamvu eziningi ezibalulekile. Noma kunjalo, uchungechunge luyenzeka futhi lubuyiselwe. Ukulandela izinhlamvu zikaPatrick Deppey noTheodore Raymond Knight, owathola uKameo ngesikhathi seshumi nesikhombisa, uSarah wasigcina uzobuyela kulo msebenzi, oshiye lo mbukiso ngo-2018.
Ngokusho kohlobo lwe-TVLL, izimo zomlingiswa wesimo sikaDrew, uDkt Eyrlil Capner, azivezwanga. Kodwa-ke, ngokungafani namaqhawe of dempley ne-knight, uDerek Shepard noGeorge O'Malley, abagawula i-heroine eyinhloko yeMeredith Grey ngemuva kokulahlekelwa ukuqaphela, ngakho-ke umlingisi angabuya ekuqondeni kwakudala. Kuzoba yisipho esincane sabalandeli bombukiso ngemuva kokushona kobuhlungu obungalindelekile kukaDkt Andrew Maker, owadlala uJacomo Gianniotti.
Khumbula, uSarah wawela wangena ku-cast of the "anatomy of Passion" ngonyaka we-2009 ngemuva kokubambisana ngempumelelo noMdali wamalungelo ochungechunge lwephrojekthi "ngaphakathi kwebhokisi." I-capner ye-eypril yavela ngesizini yesithupha njengomlingiswa ophindaphindayo, kodwa ngendima yesikhombisa yahlala njalo. UDesrew washiya le phrojekthi ngonyaka we-2018 kanye nozakwabo ochungechungeni lwe-jessica capshow.